Effect of Smoking Cessation on Vascular Function by Measurement the Flow-Mediated Dilation: A Comparative Study

Authors

  • A. Ba-Diop
  • K.N. Diong
  • F.A. Faye
  • I. Diouf
  • M. Diaw
  • A.K. Sow
  • M.S. Coly
  • A. Mbengue
  • A. Ba
  • A. Samb

DOI:

https://doi.org/10.37506/nqtg8p19

Keywords:

Smoking cessation, Vascular function, Flow mediated dilation, FMD cardiovascular risk.

Abstract

Smoking predisposes to endothelial dysfunction; however smoking cessation would have a beneficial effect on
cardiovascular risk. The objective of this study was to evaluate the effect of smoking cessation on vascular function.
Methods: This is a comparative, prospective, descriptive, and multicenter study, carried out between March 2018
and April 2021 at two Health Services of the National Gendarmerie and at the Laboratory of Physiology and
Functional Explorations of the Faculty of Medicine in Dakar, Senegal. The population included 45 consenting adult
men, divided into 3 groups: active smokers, weaned smokers, and non-smokers. We assessed vascular function
using the Flow Mediated Dilation (FMD) technique, which consisted of measuring the diameter of the humeral
artery at rest and then every 30 seconds after its occlusion.
Results: Non-smokers showed better humeral artery dilation at T1 (30 seconds after occlusion release) with a
higher mean FMD than the other 2 groups (p = 0.0007). In addition, FMD kinetics showed that control subjects as
well as weaned subjects had better arterial compliance (p < 0.05) compared to active smokers. FMD1 values were
positively correlated with smoking cessation duration (p = 0.0411; R2 = 0.3374).
Conclusion: Our results showed that stopping smoking improves vascular function and thus constitutes a
means of preventing cardiovascular diseases, hence the need to promote smoking cessation in Africa and more
particularly in Senegal.

Author Biographies

  • A. Ba-Diop

    Laboratory of Physiology and Functional Explorations, Department of Medicine, Health and Sustainable
    Development Training and Research Unit (UFRSDD), Alioune Diop University of Bambey (UADB),
    Senegal. 2IRL3189 Environment, Health, Societies CNRS-UCAD Dakar, Senegal. The African Research
    Network non-communicable diseases, Dakar, Senegal

  • K.N. Diong

    Laboratory of physiology and functional explorations, FMPOS Cheikh Anta Diop University

  • F.A. Faye

    Laboratory of Physiology and Functional Explorations, Department of Medicine, Health and Sustainable
    Development Training and Research Unit (UFRSDD), Alioune Diop University of Bambey (UADB),
    Senegal

  • I. Diouf

    Department of Physiology Laboratory, Faculty of Medicine, UFR Sante, Assane SECK University of Ziguinchor, Senegal

  • M. Diaw

    IRL3189 Environment, Health, Societies CNRS-UCAD Dakar, Senegal. The African Research
    Network non-communicable diseases, Dakar, Senegal. Laboratory of physiology and functional
    explorations, FMPOS Cheikh Anta Diop University.

  • A.K. Sow

    Laboratory of physiology and functional explorations, FMPOS Cheikh Anta Diop University.

  • M.S. Coly

    Department of Physiology Laboratory, Faculty of Medicine, UFR of Health, Iba Der Thiam University of Ziguinchor, Senegal

  • A. Mbengue

    Department of Physiology Laboratory, Faculty of Medicine, UFR of Health, Iba Der Thiam University of Ziguinchor, Senegal.

  • A. Ba

    IRL3189 Environment, Health, Societies CNRS-UCAD Dakar, Senegal. Laboratory of physiology and functional explorations, FMPOS Cheikh Anta Diop University.

  • A. Samb

    IRL3189 Environment, Health, Societies CNRS-UCAD Dakar, SenegalLaboratory of physiology and functional
    explorations, FMPOS Cheikh Anta Diop University.

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Published

2024-01-23

How to Cite

Effect of Smoking Cessation on Vascular Function by Measurement the Flow-Mediated Dilation: A Comparative Study. (2024). International Journal of Physiology, 12(1), 1-8. https://doi.org/10.37506/nqtg8p19