Effect of Smoking Cessation on Vascular Function by Measurement the Flow-Mediated Dilation: A Comparative Study
DOI:
https://doi.org/10.37506/nqtg8p19Keywords:
Smoking cessation, Vascular function, Flow mediated dilation, FMD cardiovascular risk.Abstract
Smoking predisposes to endothelial dysfunction; however smoking cessation would have a beneficial effect on
cardiovascular risk. The objective of this study was to evaluate the effect of smoking cessation on vascular function.
Methods: This is a comparative, prospective, descriptive, and multicenter study, carried out between March 2018
and April 2021 at two Health Services of the National Gendarmerie and at the Laboratory of Physiology and
Functional Explorations of the Faculty of Medicine in Dakar, Senegal. The population included 45 consenting adult
men, divided into 3 groups: active smokers, weaned smokers, and non-smokers. We assessed vascular function
using the Flow Mediated Dilation (FMD) technique, which consisted of measuring the diameter of the humeral
artery at rest and then every 30 seconds after its occlusion.
Results: Non-smokers showed better humeral artery dilation at T1 (30 seconds after occlusion release) with a
higher mean FMD than the other 2 groups (p = 0.0007). In addition, FMD kinetics showed that control subjects as
well as weaned subjects had better arterial compliance (p < 0.05) compared to active smokers. FMD1 values were
positively correlated with smoking cessation duration (p = 0.0411; R2 = 0.3374).
Conclusion: Our results showed that stopping smoking improves vascular function and thus constitutes a
means of preventing cardiovascular diseases, hence the need to promote smoking cessation in Africa and more
particularly in Senegal.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright Ownership: Authors retain copyright ownership of their work after publication in IJOP. However, they grant the journal an exclusive Creative Commons license.
Creative Commons License: The authors grant IJOP the right to exclusively apply a Creative Commons license to their work upon publication. This license permits use, distribution, and reproduction of the work in any medium, provided that the original work and its source are properly cited. The specific license applied is Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0), which allows for attribution, non-commercial use, and derivative works.
Editorial Research: Authors grant the journal the right to analyze information obtained from submitted manuscripts for editorial research purposes. This analysis aims to improve the peer-review process, teaching, and training activities.
Warranties: Authors warrant that their work is original, contains no libelous statements, is lawful, and does not infringe upon any copyright, trademark, patent, or proprietary rights of others. Authors agree to indemnify the editors against any costs, expenses, and damages arising from any breach of this warranty.
Views and Opinions: The views and opinions expressed in the article are those of the authors and not necessarily those of the journal.