Levels of Circulating Monocytes-An Indicator for Cardiovascular complications in Type 2 Diabetes
DOI:
https://doi.org/10.37506/ijop.v7i1.265Keywords:
Type 2 Diabetes, Cardiovascular complications, Monocyte count.Abstract
Background
Type 2 diabetes mellitus is mainly characterized by the development of cardiovascular complications. Inflammation is said to be involved in initiation and progression of diabetic complications related to cell damage of tissues and deepening of metabolic disturbances. Monocyte derived macrophages are believed to play a vital role in the initiation and progression of atheroma formation since monocytes grown in the presence of high glucose concentrations are in an activated and inflammatory state which is associated with the release of superoxides which has a role in oxidative stress. Studies suggest monocytes from patients with diabetes mellitus has a role in the generation of cardiovascular complications associated with diabetes. Also studies done on experimental animals suggest that depletion of monocytes and their progeny lowers the development of atherosclerosis. Thus the present study was an attempt to compare the level of circulating monocytes of diabetic subjects with cardiovascular complications with those without cardiovascular complications
Materials and Method
After taking written informed consent from the participants, under aseptic precautions around 3ml of blood was drawn using vacutainer and the levels of circulating monocytes were determined under aseptic precautions with the help of an instrument Sysmex-XS1000i.
Results and Conclusion
The results revealed that the circulating monocyte levels are significantly increased in diabetics with cardiovascular complications (p=0.04) compared to diabetics without cardiovascular complications. In support of previous studies our study opens the possibility that peripheral blood monocytes can be used to investigate the pathophysiology of diabetic complications. In the light of present idea, more studies on surface markers expressed by monocytes may be required for future risk stratification and disease-monitoring, based on knowledge of human monocyte biology.
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