The Effect of Ethanoic Extract of Xylopiaaethiopica (UDA) on Pain Sensitivity of Female Wistar Rats
DOI:
https://doi.org/10.37506/edpjgh28Keywords:
Pain Sensitivity, Xylopia aethiopica, Hot plate test.Abstract
Background: In African traditional medicine, the dried pods of Xylopia aethiopica are frequently used to manage
different human ailments. In Nigeria, it is consumed in soups after childbirth to aid in wound healing, pain
relief, uterine recovery, and lactation. The study investigates the impact of Xylopia aethiopicafruit extract on pain
sensitivity using Wistar rats.
Methods: Twelve female Wistar rats were divided into two groups (Group 1 - Control and Group 2 -100mg/kg
Xylopia aethiopicaextract-fed) and received standard rat chow and water for fourteen days following which pain
sensitivity was assessed using a hot plate. The results were presented as Mean and Independent Student T-test
was utilized for statistical analysis with significance determined at P≤0.05. Increased pain tolerance indicated
reduced sensitivity.
The escape latencies of both groups were 5secs and 8 secs respectively. Group 2 demonstrated a noteworthy
increase in pain tolerance compared to Group 1 (P = 0.003). This experimental study indicates that the ethanoic
extract of Xylopia aethiopicafruit has analgesic properties.
Conclusion: The result of this study provides support for the use of dried Xylopia aethiopicapods in pain
management across some communities in Southern Nigeria.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright Ownership: Authors retain copyright ownership of their work after publication in IJOP. However, they grant the journal an exclusive Creative Commons license.
Creative Commons License: The authors grant IJOP the right to exclusively apply a Creative Commons license to their work upon publication. This license permits use, distribution, and reproduction of the work in any medium, provided that the original work and its source are properly cited. The specific license applied is Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0), which allows for attribution, non-commercial use, and derivative works.
Editorial Research: Authors grant the journal the right to analyze information obtained from submitted manuscripts for editorial research purposes. This analysis aims to improve the peer-review process, teaching, and training activities.
Warranties: Authors warrant that their work is original, contains no libelous statements, is lawful, and does not infringe upon any copyright, trademark, patent, or proprietary rights of others. Authors agree to indemnify the editors against any costs, expenses, and damages arising from any breach of this warranty.
Views and Opinions: The views and opinions expressed in the article are those of the authors and not necessarily those of the journal.