Comparative Neuroprotective Effect of Energy Drinks

Abstract

Objective: The objective of this research was Comparative neuroprotective effect of energy drinks in
mice using various experimental animal models.
Method: The Tail suspension test (TST), Forced swim test (FST) and Y-maze test were used to assess
the antidepressant activity of the Energy drinks (Red bull, monster and enerzal) in mice. In addition,
attempts have been conducted to explore the level of brain monoamine neurotransmitters like Dopamine
and Serotonin using flame fluorimeter.
Result: The study of energy drinks on the gross behaviour of mice indicated their CNS antidepressant
effect. Furthermore, their significant (p<0.0001) antidepressant property was estimated by obtaining
its decreased immobility time of mice in tail suspension and forced swim tests. It has also exhibited
significant cognitive property performed in Y-maze apparatus. Biochemical study showed their
potentiation in the brain dopamine and serotonin concentration significantly (p<0.001) in mice which
concludes the mechanism behind their CNS depressant and cognitive properties
Conclusion: The gross behavioural study indicated their antidepressant potentiality which was further
confirmed by conducting FST and TST. Further the study showed the memory enhancement by the
EDs using Y-maze apparatus but in lesser extent. Antidepressant drugs are well evident with property
to increase dopamine and serotonin level and EDs were observed to potentiate significantly the brain
dopamine and serotonin concentration in mice.