Comparative Neuroprotective Effect of Energy Drinks

Authors

  • Irfan Khan
  • Sanjita Das
  • Shivani Shrivastava
  • Renu Singh
  • Shruti Dhasmana

DOI:

https://doi.org/10.37506/ijocm.v10i1.3204

Keywords:

Red bull, Monster, Enerzal, antidepressant, cognition, dopamine, serotonin.

Abstract

Objective: The objective of this research was Comparative neuroprotective effect of energy drinks in
mice using various experimental animal models.
Method: The Tail suspension test (TST), Forced swim test (FST) and Y-maze test were used to assess
the antidepressant activity of the Energy drinks (Red bull, monster and enerzal) in mice. In addition,
attempts have been conducted to explore the level of brain monoamine neurotransmitters like Dopamine
and Serotonin using flame fluorimeter.
Result: The study of energy drinks on the gross behaviour of mice indicated their CNS antidepressant
effect. Furthermore, their significant (p<0.0001) antidepressant property was estimated by obtaining
its decreased immobility time of mice in tail suspension and forced swim tests. It has also exhibited
significant cognitive property performed in Y-maze apparatus. Biochemical study showed their
potentiation in the brain dopamine and serotonin concentration significantly (p<0.001) in mice which
concludes the mechanism behind their CNS depressant and cognitive properties
Conclusion: The gross behavioural study indicated their antidepressant potentiality which was further
confirmed by conducting FST and TST. Further the study showed the memory enhancement by the
EDs using Y-maze apparatus but in lesser extent. Antidepressant drugs are well evident with property
to increase dopamine and serotonin level and EDs were observed to potentiate significantly the brain
dopamine and serotonin concentration in mice.

Author Biographies

Irfan Khan

M. Pharm. Research Scholar, NoidaInstitute of Engineering and Technology (Pharmacy Institute), 19,Knowledge Park-II, Greater Noida, UttarPradesh, India

Sanjita Das

Professor and HOD (Pharmacology), Noida Institute of Engineering and Technology (Pharmacy Institute), 19, Knowledge Park-II, Greater Noida, UttarPradesh, India

Shivani Shrivastava

M. Pharm. Research Scholar, Noida Institute of Engineering and Technology (Pharmacy Institute), 19, Knowledge Park-II, Greater Noida, UttarPradesh, India

Renu Singh

M. Pharm. Research Scholar, Noida Institute of Engineering and Technology (Pharmacy Institute), 19, Knowledge Park-II, Greater Noida, UttarPradesh, India

Shruti Dhasmana

M. Pharm. Research Scholar, Noida Institute of Engineering and Technology (Pharmacy Institute), 19, Knowledge Park-II, Greater Noida, UttarPradesh, India

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Published

2022-01-04