Progeria: Unraveling the Premature Aging Puzzle

Abstract

Progeria is a rare genetic disorder that accelerates the aging process in affected children. This review provides a
comprehensive overview of Progeria, including its clinical manifestations, genetic basis, molecular mechanisms,
diagnostic methods, current treatments, and ongoing research efforts. Understanding Progeria is vital for advancing
both our knowledge of aging processes and potential therapeutic strategies. Progeria (pro-JEER-e-uh), also known
as HGPS, is an extremely rare, progressive genetic disorder. It reasons children to age rapidly, preliminary in their
first two years of life. Children with progeria usually appear healthy at birth. Throughout the first year, symptoms
such as slowed growth, loss of fat tissue and hair loss begin to appear. Heart complications or strokes are the final
cause of death in most children with progeria. The usual life expectancy for a child with progeria is about 15 years.
Some with the condition may die younger and others may live longer, even to about 20 years. There’s no cure for
progeria, but new treatments and research show some potential for managing symptoms and complications.