The role of Paraoxonase 1 in Alopecia Areata, a Marker and a Severity Index

Authors

  • Hanem Elwi Omar
  • Nglaa Abd Allah
  • Sabah Ebrahim Abd Elrahim
  • Moshira Mohammed Ali

DOI:

https://doi.org/10.37506/ijocm.v10i2.3272

Keywords:

Alopecia areata; Paraoxonase1; Oxidative stress.

Abstract

Background: Alopecia areata (AA) is an immune-mediated form of hair loss that affects all ages and both sexes.
Paraoxonase 1 (PON1) is an esterase enzyme that has lipophilic antioxidant power; it is one of the endogenous
free-radical-scavenging systems in the human body. This work was to detect serum PON1 level in patients with
alopecia areata.
Methods: 60 subjects, 30 AA patients and 30 controls. Full history, general and local clinical examination, clinical
assessment of the degree of AA and collection of blood for investigations and paraoxonase1 measurement were
to participants.
Results: The study revealed significant decrease in serum PON1 level in AA patients (54.083 ± 25.464 μg/L) in
comparison to controls (69.479 ± 17.012 μg/L). This decrease was more in male than female.
Conclusions: Serum PON1 levels are lower in AA patients. An association between oxidative stress and
pathogenesis of this auto immune disease is identified. Attenuation of oxidative stress might be a relevant
therapeutic approach and it would be useful to recommend additional drugs with antioxidant effect for treatment.

Author Biographies

Hanem Elwi Omar

Researcher of Dermatology, Faculty of medicine, Al-azhar University for girls, Cairo, Egypt

Nglaa Abd Allah

Professor of Dermatology, Faculty of medicine, Al-azhar University for girls, Cairo, Egypt

Sabah Ebrahim Abd Elrahim

Professor of Clinical Pathology, Faculty of medicine, Al-azhar University for girls, Cairo, Egypt

Moshira Mohammed Ali

Professor of Dermatology, Faculty of medicine, Al-azhar University for girls, Cairo, Egypt

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Published

2022-07-12