The role of Paraoxonase 1 in Alopecia Areata, a Marker and a Severity Index
Keywords:Alopecia areata; Paraoxonase1; Oxidative stress.
Background: Alopecia areata (AA) is an immune-mediated form of hair loss that affects all ages and both sexes.
Paraoxonase 1 (PON1) is an esterase enzyme that has lipophilic antioxidant power; it is one of the endogenous
free-radical-scavenging systems in the human body. This work was to detect serum PON1 level in patients with
Methods: 60 subjects, 30 AA patients and 30 controls. Full history, general and local clinical examination, clinical
assessment of the degree of AA and collection of blood for investigations and paraoxonase1 measurement were
Results: The study revealed significant decrease in serum PON1 level in AA patients (54.083 ± 25.464 μg/L) in
comparison to controls (69.479 ± 17.012 μg/L). This decrease was more in male than female.
Conclusions: Serum PON1 levels are lower in AA patients. An association between oxidative stress and
pathogenesis of this auto immune disease is identified. Attenuation of oxidative stress might be a relevant
therapeutic approach and it would be useful to recommend additional drugs with antioxidant effect for treatment.